COMPOSITIONS AND METHODS FOR MODULATING MYELOID DERIVED SUPPRESSOR CELLS
摘要
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (MDSC). In particular, described herein are miR-142 polynucleotides and miR-223 polynucleotides that can be used to modulate differentiation of MDSCs. Increased differentiation of a MDSC population, or cells within an MDSC population, can be achieved by increasing the miR-142 and/or miR-223 polynucleotides in a MDSC.
申请公布号
WO2013082591(A1)
申请公布日期
2013.06.06
申请号
WO2012US67586
申请日期
2012.12.03
申请人
UNIVERSITY OF SOUTH FLORIDA;MOHAPATRA, SHYAM, S.;NAGARAJ, SRINIVAS;MOHAPATRA, SUBHRA