METHOD FOR PREPARING PHARMACEUTICAL MICROCAPSULES OF CEPHALOSPORINS

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutical microcapsulation of cephalosporins related to ?-lactam antibiotics. As a microcapsule shell, the method of pharmaceutical microcapsulation of cephalosporins uses konjac gum; the microcapsules are prepared by physical-chemical technology implying the precipitation in a non-solvent using two precipitants - carbinol and diethyl ester in ratio 1:3; the method is conducted at 25°C with no special equipment.EFFECT: invention provides simplified and accelerated preparation of the water-soluble pharmaceutical microcapsules of cephalosporins in konjac gum, loss reduction in preparing the microcapsules (higher yield-mass).3 ex