| 发明名称 |
THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS |
| 摘要 |
<p>The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included. (Formulas I and II).</p> |
| 申请公布号 |
EP2054401(B1) |
申请公布日期 |
2013.05.01 |
| 申请号 |
EP20070815782 |
申请日期 |
2007.08.10 |
| 申请人 |
MERCK CANADA INC. |
发明人 |
BLOUIN, MARC;BURCH, JASON;YONGXIN, HAN;MELLON, CHRISTOPHE |
| 分类号 |
C07D333/38;A61K31/381;A61K31/41;A61K31/425;A61K31/433;A61P19/02;A61P29/00;C07D275/03;C07D285/10;C07D409/12 |
主分类号 |
C07D333/38 |
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