| 摘要 |
FIELD: chemistry.SUBSTANCE: method of producing 16?,17?-cyclohexano-5,6-epoxypregn-3?-ol-20-one acetate involves treatment of 16?,17?-cyclohexanopregn-5-en-3?-ol-20-one acetate with p-carbomethoxyperbenzoic acid in a medium of polar methylene chloride and the process is carried out at temperature of 25-30°C and molar ratio of 16?,17?-cyclohexanopregn-5-en-3?-ol-20-one acetate: p-carbomethoxyperbenzoic acid of 1:1.1-1.5. The end product contained in the solution is easily separated after filtering the p-carbomethoxybenzoic acid precipitate.EFFECT: safety and simplification of the disclosed method and increase in directivity of the process towards obtaining an -isomer of the end product; invention can be used to produce an intermediate product during synthesis of pregnane steroid hormones which are valuable hormonal agents used in medicine.2 cl, 4 ex |
