Treatment and prevention of influenza

摘要

Disclosed is a nucleic acid construct encoding three RNA molecules comprising a double stranded region, wherein the RNA molecules reduce influenza A virus replication in an animal cell and/or reduce production of infectious influenza A virus particles in an animal cell and/or reduce the expression of an influenza A virus polypeptide in an influenza A virus infected animal cell when compared to an isogenic influenza A virus infected animal cell lacking the RNA molecules, wherein the double-stranded regions comprise nucleotide sequences at least 95% identical to: (i) SEQ ID NO:9, SEQ ID NO:13 and SEQ ID NO:15.