发明名称 |
Doxycycline metal complex in a solid dosage form |
摘要 |
The present invention is a solid dosage form of a doxycycline metal complex. The present invention also includes a process for making a doxycycline metal complex in a solid dosage form. The process comprises the steps of (i) providing an aqueous solution of doxycycline or a physiologically acceptable salt thereof; (ii) admixing a metal salt with the aqueous solution; (iii) admixing a base to increase the pH of the aqueous solution, thereby forming a suspension of doxycycline metal; and (iv) drying the suspension, thereby forming a dry granulation of doxycycline metal complex. |
申请公布号 |
US8415331(B2) |
申请公布日期 |
2013.04.09 |
申请号 |
US20080338491 |
申请日期 |
2008.12.18 |
申请人 |
DEVRIES TINA;GOLD LYNN;WARNER CHILCOTT COMPANY, LLC |
发明人 |
DEVRIES TINA;GOLD LYNN |
分类号 |
A61K31/65;A61K9/16;A61K9/20;A61K9/48;A61P31/04 |
主分类号 |
A61K31/65 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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