发明名称 |
A DEVICE FOR THE TRANSDERMAL DELIVERY OF ALKALINE COMPOUNDS THAT ARE SUSCEPTIBLE TO DEGRADATION IN THEIR FREE BASE FORM |
摘要 |
<p>The present invention pertains generally to the field of transdermal drug delivery. More specifically, the invention relates to a device for the transdermal delivery of an alkaline pharmaceutically active compound that is susceptible to degradation in its free base form (e.g., rivastigmine) that comprises an adhesive matrix layer, a backing layer and a release or protective layer, wherein the adhesive matrix layer comprises said pharmaceutically active compound, triethylcitrate and hydrochloric acid. The invention also relates to methods of preparing such devices.</p> |
申请公布号 |
WO2013027052(A1) |
申请公布日期 |
2013.02.28 |
申请号 |
WO2012GB52047 |
申请日期 |
2012.08.21 |
申请人 |
AMARIN TECHNOLOGIES S.A.;SCASSO, ALEJANDRO FABIO;STEFANO, FRANCISCO JOSE EVARISTO |
发明人 |
SCASSO, ALEJANDRO FABIO;STEFANO, FRANCISCO JOSE EVARISTO |
分类号 |
A61K31/135;A61K9/70;A61K31/137;A61K31/165;A61K31/27;A61K31/4045;A61K31/407;A61K31/465;A61K31/473;A61K47/02;A61K47/14;A61K47/38 |
主分类号 |
A61K31/135 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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