发明名称 |
NOVEL ANTI-HUMAN NGF ANTIBODY |
摘要 |
<p>[Problem] To provide: an anti-human NGF antibody which is reduced in the influence on fetuses and the risk of adverse side effects including thrombosis while keeping a high neutralizing activity, and which has excellent safety, or an antigen-binding fragment thereof; and a means for preventing or treating various diseases for which human NGF is involved in the development of a disease state, which utilizes the antibody or an antigen-binding fragment thereof. [Solution] An Fab' fragment of an anti-human NGF antibody, which comprises a heavy-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 6 and a light-chain variable region comprising the amino acid sequence represented by SEQ ID NO: 4.</p> |
申请公布号 |
CA2841181(A1) |
申请公布日期 |
2013.02.14 |
申请号 |
CA20122841181 |
申请日期 |
2012.08.10 |
申请人 |
ASTELLAS PHARMA INC. |
发明人 |
KAMOHARA, MASAZUMI;TANAKA, HIROTSUGU;KOYA, YUKARI;TAKASAKI, JUN;YONEZAWA, ATSUO;YOSHIMI, EIJI |
分类号 |
C12N15/09;C07K16/22;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/08 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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