发明名称 |
Protein microspheres having injectable properties at high concentrations |
摘要 |
The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins. |
申请公布号 |
US8333995(B2) |
申请公布日期 |
2012.12.18 |
申请号 |
US20050127704 |
申请日期 |
2005.05.12 |
申请人 |
BROWN LARRY;BISKER-LEIB VERED;LAFRENIERE DEBRA;MCGEEHAN JOHN;RASHBA-STEP JULIA;SCOTT TERRENCE;BAXTER INTERNATIONAL, INC.;BAXTER HEALTHCARE S.A. |
发明人 |
BROWN LARRY;BISKER-LEIB VERED;LAFRENIERE DEBRA;MCGEEHAN JOHN;RASHBA-STEP JULIA;SCOTT TERRENCE |
分类号 |
A61K39/395;A61K9/16;A61K39/00;A61K47/42;C07K16/28;C07K16/36 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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