发明名称 |
ORGANIC COMPOUNDS |
摘要 |
The present invention relates to a novel selection system for use in a eukaryotic cell culture process and for expression of a recombinant product of interest. The selection system is based on the introduction of an exogenous functional membrane-bound folate receptor gene together with the polynucleotide or gene encoding the product of interest into a eukaryotic cell and can be widely utilized with eukaryotic cells for which cellular viability is dependent upon folic acid uptake. |
申请公布号 |
US2012276579(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
US201213495043 |
申请日期 |
2012.06.13 |
申请人 |
ASSARAF YEHUDA G.;JOSTOCK THOMAS;KNOPF HANS-PETER;NOVARTIS AG |
发明人 |
ASSARAF YEHUDA G.;JOSTOCK THOMAS;KNOPF HANS-PETER |
分类号 |
C12P21/00;C12N5/10;C12N15/85;C12N15/87;C12P19/34;C12Q1/04 |
主分类号 |
C12P21/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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