HUMAN PARAINFLUENZA VIRUSES HAVING SEPARATED P AND C GENES
摘要
<p>The invention provides self replicating infectious recombinant paramyxoviruses where the P and C genes are separated rated. The recombinant paramyxoviruses preferably have one or more attenuating mutations and/or at least one temperature sensitive mutation and one non-temperature sensitive mutation. In some embodiments, the recombinant paramyxovirus has a separate variant polynucleotide encoding a C protein and a separate monocistronic polynucleotide encoding a P protein. Also provided are compositions and methods for using the recombinant paramyxoviruses as described herein.</p>
申请公布号
EP2152863(B1)
申请公布日期
2012.09.19
申请号
EP20080780603
申请日期
2008.05.08
申请人
GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人
COLINS, PETER L.;MURPHY, BRIAN R.;SKIADOPOULOS, MARIO H.;BARLETT, EMMALENE J.;SCHMIDT, ALEXANDER C.;CRUZ, ANN-MARIE, M.