The present invention concerns antigen binding proteins and fragments thereof which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and which inhibit the binding of OSM to the gp130 receptor but does not directly interact with site II residues. The invention also concerns a method of humanising antibodies. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
申请公布号
WO2012069433(A3)
申请公布日期
2012.08.09
申请号
WO2011EP70604
申请日期
2011.11.21
申请人
GLAXO GROUP LIMITED;BEMBRIDGE, GARY PETER;CHUNG, CHUN-WA;FEENEY, MARIA;FORD, SUSANNAH KAREN;KIRBY, IAN;MCADAM, RUTH
发明人
BEMBRIDGE, GARY PETER;CHUNG, CHUN-WA;FEENEY, MARIA;FORD, SUSANNAH KAREN;KIRBY, IAN;MCADAM, RUTH