发明名称 |
METHOD FOR PRODUCING 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE |
摘要 |
<p>The present invention provides a method for commercially advantageously producing, at low cost, an optically active form of an anti-(3S,4R)-3-alkylcarbamoyl-4-hydroxy pyrrolidine derivative or an enantiomer thereof that is a key intermediate for the production of a high-quality optically active form of (3R,4S)-3-alkylaminomethyl-4-fluoropyrrolidine or an enantiomer thereof that is useful as a production intermediate for a pharmaceutical product. The present invention relates to a method for producing an optically active anti-(3S,4R)-4-hydroxy pyrrolidine-3-carboxylic acid amide derivative or an enantiomer thereof by asymmetric hydrogenation of a 4-oxopyrrolidine-3-carboxylic acid amide derivative represented by general formula (I) using an optically active catalyst. (In formula (I), PG1 represents a protecting group of an amino group; and R1 represents hydrogen, an optionally substituted C1-C6 alkyl group or an optionally substituted C3-C8 cycloalkyl group.)</p> |
申请公布号 |
CA2815952(A1) |
申请公布日期 |
2012.05.03 |
申请号 |
CA20112815952 |
申请日期 |
2011.10.24 |
申请人 |
KYORIN PHARMACEUTICAL CO., LTD. |
发明人 |
ARAYA, ICHIRO;KIYOTA, KOICHI;NAGAO, MUNEKI |
分类号 |
C07D207/24;C07B53/00;C07B61/00;C07C269/06 |
主分类号 |
C07D207/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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