COMPOSITIONS AND METHODS FOR TREATING CANCER AND METHODS FOR PREDICTING A RESPONSE TO SUCH TREATMENTS

摘要

The present disclosure relates to the regulation and function of the Wnt/&bgr;-catenin signaling pathway and the ERK signaling pathway. The disclosure provides methods of treatment for melanoma by administering both an inhibitor of ERK signaling and an activator of Wnt/&bgr;-catenin signaling. These methods may be used alone or in combination with other strategies targeting melanoma cell survival. The disclosure also provides diagnostic methods for predicting a patient's clinical response to inhibitors of ERK signaling.