发明名称 |
Molecular Adaptors for Dye Conjugates |
摘要 |
In various embodiments, the present invention provides fluorescent dyes that are linked to another species through an adaptor moiety. In an exemplary embodiment, the dye is linked to a polyphosphate nucleic acid through an adaptor. An adaptor can be a component of a linker. These conjugates find use in single molecule DNA sequencing and other applications. In various embodiments, the dye moiety is a cyanine dye. Cyanine dyes that are highly charged, such as those including multiple sulfonate, alkylsulfonate, carboxylate and/or alkylcarboxylate moieties are examples of cyanine dyes of use in the compounds of the invention.
|
申请公布号 |
US2012058473(A1) |
申请公布日期 |
2012.03.08 |
申请号 |
US201113218439 |
申请日期 |
2011.08.25 |
申请人 |
YUE STEPHEN;SHEN GENE;BROGLEY LOUIS;SEBO LUBOMIR;WEGENER JEFFREY;PACIFIC BIOSCIENCES OF CALIFORNIA, INC. |
发明人 |
YUE STEPHEN;SHEN GENE;BROGLEY LOUIS;SEBO LUBOMIR;WEGENER JEFFREY |
分类号 |
C12Q1/68;C07H19/10;C07H19/207;C07K17/10 |
主分类号 |
C12Q1/68 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|