发明名称 |
HYDROGELS FOR COMBINATORIAL DELIVERY OF IMMUNE-MODULATING BIOMOLECULES |
摘要 |
<p>One embodiment of the current disclosure relates to an immune-modulating composition comprising a hydrogel-forming polymer, an immune-modulating biomolecule operable to recruit or retain an immune cell, and an antigen-related biomolecule. Another embodiment of the current disclosure relates to a method of providing an antigen to an antigen presenting cell in an animal by administering to the animal at an administration site an immune-modulating composition as described above. Next, one forms a hydrogel in-situ from the hydrogel-forming polymer, then recruits at least one antigen presenting cell to the administration site using the immune-modulating biomolecule, and finally inducing phagocytosis of the at least one antigen-related biomolecule by the antigen presenting cell.</p> |
申请公布号 |
EP2421505(A2) |
申请公布日期 |
2012.02.29 |
申请号 |
EP20100767686 |
申请日期 |
2010.04.21 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
SINGH, ANKUR;ROY, KRISHNENDU;KASTURI, SUDHIR |
分类号 |
A61K9/06;A61K39/395;A61K47/34;A61K47/40;A61P31/00;A61P37/00 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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