发明名称 |
METHOD FOR PREPARING MICROSPHERES AND MICROSPHERES PRODUCED THEREBY |
摘要 |
The present invention relates to a method for preparing microsphere and microspheres produced by thereby. More particularly, the present invention relates to a method for preparing a polymeric microsphere comprising the steps of: mixing a water-insoluble organic solvent with a dispersion solvent; mixing a polymer compound, a drug and a water-insoluble organic solvent so as to prepare a dispersed phase; mixing the dispersed phase with the dispersion solvent mixed with the water-insoluble organic solvent so as to prepare an emulsion; and adding a base or an acid to the prepared emulsion so as to remove the water-insoluble organic solvent from the emulsion and a polymeric microsphere thereby, and a composition for drug delivery comprising the microspheres. In the inventive preparation method, it is possible to conveniently prepare a drug-containing polymeric microsphere within a short time using a small amount of water, with the generation of a minimized amount of waste solution without a requirement of a conventional solvent-evaporation or solvent-extract ion process. Also, since a low concentration of remaining solvent within a prepared polymeric microsphere can be maintained, it is effective in preparation in sustained-release type medicines.
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申请公布号 |
CA2805430(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
CA20112805430 |
申请日期 |
2011.07.20 |
申请人 |
EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION;SK CHEMICALS CO., LTD. |
发明人 |
SAH, HONG KEE;LEE, BONG-YONG;UM, KEY-AN;OH, JOON-GYO;HWANG, YONG YOUN;KIM, HONG-KEE;LEE, KYU HO;HONG, SEOK HYUN;LEE, YOON-JUNG |
分类号 |
A61K9/14;A61K9/22;A61K31/57;C08J3/12 |
主分类号 |
A61K9/14 |
代理机构 |
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