发明名称 |
METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE |
摘要 |
Dosage forms and methods for providing a substantially ascending rate of release of paliperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone concentration that occurs following administration of paliperidone in an immediate-release dosage form. |
申请公布号 |
PL210119(B1) |
申请公布日期 |
2011.12.30 |
申请号 |
PL20030376258 |
申请日期 |
2003.07.28 |
申请人 |
ALZA CORPORATION |
发明人 |
YAM NOYMI V.;REYES IRAN;DAVAR NIPUN;AYER ATUL D.;LEE JULIE |
分类号 |
A61K9/24;C07D471/04;A61K9/00;A61K9/30;A61K9/62;A61K31/506;A61K31/519;A61P25/18;A61P25/22;A61P25/24 |
主分类号 |
A61K9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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