| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a new and improved low-concentration formulation of an active enamel substance, such as an enamel matrix, enamel matrix derivative and/or an enamel matrix protein, intended to be used as a therapeutic, as a prophylactic and/or as a cosmetic agent. <P>SOLUTION: The active enamel substance can be incorporated into a polymeric matrix, which is either suitable for cellular in-growth, or cell-occlusive. The active enamel substance can be incorporated into the polymeric matrix so that it is released by degradation of the polymeric matrix, by enzymatic action and/or by diffusion. Thus in particular, a new pharmaceutical and/or cosmetic formulation of an active enamel substance at lower total concentration within the formulation is included and a spatial and/or selective regulation of release of the active enamel substance permits a greater percentage of the active enamel substance to be released at the time of appropriate cellular activity. <P>COPYRIGHT: (C)2012,JPO&INPIT |
