发明名称 |
METHODS FOR TREATING IMMUNE-MEDIATED DENGUE FEVER INFECTIONS AND ANTIBODY-DEPENDENT ENHANCEMENT OF DENGUE FEVER INFECTIONS, INCLUDING DENGUE HEMORRHAGIC FEVER AND DENGUE SHOCK SYNDROME. |
摘要 |
<p>Polypeptides and other compounds that can bind specifically to the CH2-CH3 cleft of an immunoglobulin molecule, and methods for using such polypeptides and compounds to inhibit Fc-mediated immune complex formation in viral infection. For example, polypeptides and other compounds can be used to inhibit binding of DF-associated, immune-complexed IgG anti-DF viron(s) or DV viral antigens to F?R, ADE of DF/DHF/DSS infections by inhibition of DF viral antigen binding to immune complexed IgG, F?R and immune complexed IgG mC1q (membrane C1q) or soluble C1q binding.</p> |
申请公布号 |
MX2011000647(A) |
申请公布日期 |
2011.09.29 |
申请号 |
MX20110000647 |
申请日期 |
2009.07.17 |
申请人 |
TRINITY THERAPEUTICS, INC. |
发明人 |
NEIL M. BODIE |
分类号 |
A61K38/10;A61P31/12;A61P37/00 |
主分类号 |
A61K38/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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