发明名称 |
METHODS OF DIFFERENTIATING AND PROTECTING CELLS BY MODULATING THE P38/MEF2 PATHWAY |
摘要 |
The present invention provides a method of differentiating progenitor cells to produce a population containing protected neuronal cells. A method of the invention includes the steps of contacting the progenitor cells with a differentiating agent; and introducing into the progenitor cells a nucleic acid molecule encoding a MEF2 polypeptide or an active fragment thereof, thereby differentiating the progenitor cells to produce a population containing protected neuronal cells. In one embodiment, the MEF2 polypeptide is human MEF2C or an active fragment thereof.
|
申请公布号 |
US2011212070(A1) |
申请公布日期 |
2011.09.01 |
申请号 |
US201113077752 |
申请日期 |
2011.03.31 |
申请人 |
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE |
发明人 |
LIPTON STUART A.;OKAMOTO SHU-ICHI |
分类号 |
A61K35/30;A61K35/12;A61P25/00;A61P25/16;A61P25/28;C12N5/0793;C12N15/85;G01N33/68 |
主分类号 |
A61K35/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|