发明名称 |
POLYMER CONJUGATES OF NEUBLASTIN AND METHODS OF USING SAME |
摘要 |
A variant neublastin polypeptide suitable for formation of a conjugate comprising the variant neublastin polypeptide coupled to a polymer containing a polyalkylene glycol moiety is disclosed. The present conjugate has prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to non-modified or wild-type forms of neublastin. The conjugates of the invention are usefully employed in therapeutic as well as non-therapeutic, e.g., diagnostic, applications. |
申请公布号 |
CA2436407(C) |
申请公布日期 |
2011.08.30 |
申请号 |
CA20022436407 |
申请日期 |
2002.01.25 |
申请人 |
BIOGEN, INC. |
发明人 |
SAH, DINAH WEN-YEE;PEPINSKY, R. BLAKE;BORIACK-SJODIN, PAULA ANN;MILLER, STEPHAN S.;ROSSOMANDO, ANTHONY |
分类号 |
C12N15/09;C12N15/12;A61K38/00;A61K38/18;A61K39/00;A61K47/48;A61P3/10;A61P9/10;A61P13/12;A61P21/00;A61P25/00;A61P25/02;A61P25/04;A61P25/14;A61P25/16;A61P25/28;A61P29/02;A61P35/00;C07K14/00;C07K14/475;C07K14/765;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/63;C12P21/00;C12P21/02 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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