METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION

摘要

This invention relates to the use of agents that modulate claudin-l and/or -23 expression or activity for purposes of regulating tight junction ("TJ") formation among keratinocytes that express claudin-l and/or -23, or other cell types that over- or under-express claudin-l and/or -23. Several aspects of the present invention relate to increasing claudin-l and/or -23 expression or function to enhance tight junction formation among claudin-l and/or -23 expressing cells, particularly keratinocyte and antigen presenting cells. Several other aspects of the invention relate to decreasing claudin-l and/or -23 expression or function to diminish tight junction formation among claudin-l and/or -23 expressing cells, particularly keratinocytes and antigen presenting cells. Transdermal drug and vaccine fomnulations including agent(s) that decrease -1 and/or -23 expression or function to diminish tight junction formation among claudin-l and/or -23 expressing cells, as well as a trans dermal patch for delivering the same, are also included.