METHOD OF PREPARING AN IMMUNOLOGICALLY-ACTIVE ADJUVANT-BOUND DRIED VACCINE COMPOSITION

摘要

The disclosure provides a method of preparing an immunologically-active adjuvant-bound freeze dried vaccine composition. A specific embodiment provides a stable vaccine composition comprising an aluminum-salt adjuvant, a recombinant Clostridium botulinum neurotoxin protein and a glass-forming agent. These vaccine compositions are useful in the treatment of humans and other animals at risk of infection from Clostridium botulinum neurotoxin.