Carbon nanoparticles with a covalent bond to a target molecule through a bridging molecule and method for producing same

摘要

Covalently linking target molecules on carbon nanoparticles by at least one bridging molecule, comprises: (a) reacting carbon nanoparticles with a carbonyl compound of at least one bridging molecule in presence of a Lewis acid under Friedel-Craft reaction conditions to obtain acyl-carbon-nanoparticles, which possess a nucleofuge in omega-position; and (b) covalently linking the target molecule to the omega-substituted acyl-carbon-nanoparticles by nucleophilic substitution of the nucleofuge in omega-position. An independent claim is also included for modified carbon nanoparticles that are covalently bonded to the target molecule by at least one bridging molecule, where the bridging molecule is bonded to the carbon nanoparticles by a carbonyl group and is further bonded to the target molecule by an ester-, a thioester-, an amide-, an ether-, a thioether- or an amine group, and the modified carbon nanoparticles comprise a hydrocarbon-, polyethylene glycol- or siloxane chain between the carbon nanoparticles and the target molecule.