发明名称 |
NOVEL PHENYLPYRIDINE DERIVATIVE AND MEDICINAL AGENT COMPRISING SAME |
摘要 |
<p>Disclosed are: a novel compound which has both an antagonistic activity on an angiotensin II receptor and a PPAR?-activating activity and is therefore useful as a prophylactic and/or therapeutic agent for hypertension, heart diseases, arteriosclerosis, type-2 diabetes, diabetic complications, metabolic syndrome or the like; and a pharmaceutical composition containing the compound. Specifically disclosed are: a compound represented by general formula (I) (wherein the ring A represents a pyridine ring; the ring B represents a tetrazole ring or an oxadiazol-5(4H)-one ring; X represents C-R5 or a nitrogen atom; R1 represents a C1-6 alkyl group; R2 represents a C1-6 alkyl group or a C3-8 cycloalkyl group; and R3, R4, R5 independently represent a hydrogen atom, a halogen atom, a C1-6 alkyl group, a halo-C1-6 alkyl group, or a C1-6 alkoxy group which may have a substituent), a salt of the compound, or a solvate of the compound or the salt; and a pharmaceutical composition containing the compound, the salt or the solvate.</p> |
申请公布号 |
WO2011040004(A1) |
申请公布日期 |
2011.04.07 |
申请号 |
WO2010JP05842 |
申请日期 |
2010.09.29 |
申请人 |
KOWA COMPANY, LTD.;MIURA, TORU;SATO, SEIICHI;YAMADA, HAJIME;TAGASHIRA, JUNYA;SEKIMOTO, RYOHEI;ISHIDA, RIE;AOKI, HITOMI;OHGIYA, TADAAKI |
发明人 |
MIURA, TORU;SATO, SEIICHI;YAMADA, HAJIME;TAGASHIRA, JUNYA;SEKIMOTO, RYOHEI;ISHIDA, RIE;AOKI, HITOMI;OHGIYA, TADAAKI |
分类号 |
C07D401/14;A61K31/506;A61P3/00;A61P3/04;A61P3/06;A61P3/10;A61P9/00;A61P9/10;A61P9/12;A61P13/12;A61P25/00;A61P27/02;A61P43/00;C07D413/14 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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