发明名称 |
6-(Pyridinyl)-4-pyrimidone derivatives as tau protein kinase 1 inhibitors |
摘要 |
A compound represented by the formula (I), an optically active isomer thereof, or a pharmaceutical acceptable salt thereof: wherein R 1 represents a C 1 -C 12 alkyl; R 2 represents a hydrogen atom or the like; R 3 represents a halogen or the like; q represents an integer of 1 to 7; R 4 represents a halogen or the like; p represents 0 or an integer of 1 to 5; R 5 represents a C 6 -C 10 aryl, a heterocycle or the like; and X represents oxygen, NH, or the like, which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).
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申请公布号 |
EP2261224(A2) |
申请公布日期 |
2010.12.15 |
申请号 |
EP20100010448 |
申请日期 |
2005.09.29 |
申请人 |
MITSUBISHI TANABE PHARMA CORPORATION;SANOFI-AVENTIS |
发明人 |
WATANABE, KAZUTOSHI;FUKUNAGA, KENJI;KOHARA, TOSHIYUKI;UEHARA, FUMIAKI;HIKI, SHINSUKE;YOKOSHIMA, SATOSHI |
分类号 |
C07D401/04;A61K31/505;A61K31/506;A61P25/28;C07D401/14;C07D409/14;C07D413/14 |
主分类号 |
C07D401/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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