发明名称 |
Exocrine gland tight junction-constituting protein jeap family |
摘要 |
A mouse cDNA library from gene fragments encoding proteins localizing at cell-cell junctions was screened by a technique visualizing localization of a protein to identify a junction-enriched and -associated protein, JEAP. GenBank homology search was performed based on the sequence. Based on the obtained sequence, a mouse cDNA library was screened to identify JEAP-2. By using prepared antibodies against these proteins, it was revealed that these proteins express specifically at tight junctions, in particular, tight junctions in exocrine glands.
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申请公布号 |
US7824676(B2) |
申请公布日期 |
2010.11.02 |
申请号 |
US20060522043 |
申请日期 |
2006.09.15 |
申请人 |
EISAI R&D MANAGEMENT CO., LTD. |
发明人 |
NISHIMURA MIYUKI;ASANO MAYUMI;ONO YUICHI;MORIMOTO KOJI;TAKEUCHI MASAKAZU;INOUE YOKO;IMAI TOSHIO;TAKAI YOSHIMI |
分类号 |
C07K16/18;C07K14/47;C07K14/705;C12N15/12 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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