发明名称 |
Antigen-Specific T-Cell Preparations from Bone Marrow |
摘要 |
A method for the generation of antigen-specific T-cell preparations for adoptive therapy is provided, comprising the steps of obtaining lymphoid cells from the bone marrow of a patient in a first step, expanding the lymphoid cells in cell culture medium ex-vivo in the presence of at least one of IL2 and IL7 and or more antigens, yielding a T-cell preparation, and isolating the T-cell preparation from the culture medium in an isolation step. T-cell preparations provided according to the inventive method, and the use of such T-cell preparations for the treatment of infectious disease and cancer is also provided.
|
申请公布号 |
US2010254958(A1) |
申请公布日期 |
2010.10.07 |
申请号 |
US20080739786 |
申请日期 |
2008.10.24 |
申请人 |
LETSCH ANNE;SCHEIBENBOGEN CARMEN;NA IL-KANG;VOLK HANS-DIETER |
发明人 |
LETSCH ANNE;SCHEIBENBOGEN CARMEN;NA IL-KANG;VOLK HANS-DIETER |
分类号 |
A61K35/28;A61P31/12;C12N5/0783 |
主分类号 |
A61K35/28 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|