POLYMERIC IMMOBILIZATION MATRIX FOR LIVE-CELL BIOSENSORS
摘要
<p>The present invention relates to a portable device for the detection of analytes, in particular toxic substances, comprising at least a whole-cell biosensor with cells immobilized onto a transparent and inert matrix that allows the maintenance of cell vitality. The matrix comprises a mixture of collagen and/or its enzyme degradation derivatives, a proteoglycan and a mixture of vinyl polymer and an optionally modified polysiloxane, and an orthosilicate. The biosensor can be a genetically modified cell that expresses luciferase as reporter gene.</p>
申请公布号
WO2010092539(A1)
申请公布日期
2010.08.19
申请号
WO2010IB50625
申请日期
2010.02.11
申请人
ALMA MATER STUDIORUM UNIVERSITA DI BOLOGNA;MICHELINI, ELISA;RODA, ALDO;DOLCI, LUISA STELLA;CEVENINI, LUCA;MEZZANOTTE, LAURA
发明人
MICHELINI, ELISA;RODA, ALDO;DOLCI, LUISA STELLA;CEVENINI, LUCA;MEZZANOTTE, LAURA