发明名称 |
HEPOXILIN ANALOG ENANTIOMERS |
摘要 |
The present invention relates to enantiomeric forms of hepoxilin analogs of Formula I-VIII, pharmaceutical compositions thereof, a method for the separation of said enantiomeric forms of hepoxilin analogs comprising applying said hepoxilin to a chiral phase HPLC column and eluting said hepoxilin with an alkane and alcohol solvent mixture. Said enantiomeric forms of hepoxilin analogs of Formula I-VIII were found to be useful in controlling the biological effects of PPAR mediated transcriptional control for the treatment of diseases such as cancer, thromboxane-mediated diseases and for modulating intracellular calcium concentration.
|
申请公布号 |
US2010210727(A1) |
申请公布日期 |
2010.08.19 |
申请号 |
US20070226457 |
申请日期 |
2007.04.19 |
申请人 |
EVOLVA S.A. |
发明人 |
PACE-ASCIAK CECIL;SORENSEN ALEXANDRA SANTANA;MEYER JEAN-PHILIPPE;DEMIN PETER |
分类号 |
A61K31/202;A61P1/00;A61P1/16;A61P3/10;A61P9/10;A61P11/06;A61P25/06;A61P25/28;A61P27/02;A61P29/00;A61P31/12;A61P35/00;A61P37/00;C07C59/11 |
主分类号 |
A61K31/202 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|