DERIVATIVES OF 6-(6-O-SUBSTITUTED-TRIAZOLOPYRIDAZINE-SULFANYL) BENZOTHIAZOLES AND BENZIMIDAZOLES, PREPARATION THEREOF, USE THEREOF AS DRUGS, AND USE THEREOF AS MET INHIBITORS

摘要

The invention relates to novel products of the formula (I) where: (II) is a single double bond; Ra is -O-Z-Rc with Z being a single bond or optionally substituted alkylene and Rc being optionally substituted cycloalkyl, heterocycloalkyl, aryl or heteroaryl; Rb is H or F; if Rb is H, then Rc is not cycloalkyl when Z is a single bond, and Rc is not heterocycloalkyl when Z is alkylene; X is S, SO or SO2, A is NH or S; W is H, alkyl, cycloalkyl or COR with R being cycloalkyl; alkyl; alkoxy; O- phenyl; -O-(CH2)n-phenyl with n = 1 to 4; or NR1 R2 with R1 is H or alk and R2 is H, cycloalkyl or alkyl; or R1, R2 form a cycle with N optionally containing O, S, N and/or NH; wherein all of these radicals are optionally substituted, and said products are in any isomer or salt form and can be used as drugs, in particular as MET inhibitors.