| 摘要 |
Processes for the preparation of Caralluma extract which includes shade-drying of Caralluma plant material; ii) treating the dried Caralluma plant material by at least one operation selected from a group consisting of sorting, cleaning and sizing to obtain Caralluma plant material meant for extraction or any combination thereof; iii) extracting the Caralluma plant material with a first solvent for at least two initial iterations followed by at least two subsequent iterations with a second solvent at controlled temperature to obtain a diluted extract; iv) removing the solvent from the diluted extract by distillation at a temperature below about 40° C. to obtain a concentrate; v) chilling the concentrate at a temperature of about 6 to about 10° C. for a period of about 7 to about 8 hours to obtain a chilled concentrate; vi) filtering the chilled concentrate to obtain a filtrate; vii) concentrating the filtrate at a temperature below about 60° C. to obtain a viscous liquid; viii) spray-drying the concentrated viscous liquid to obtain a powder; and ix) pulverizing and sifting the dried powder to obtain a Caralluma extract provided. Such extracts may be included in medicinal formulations used for the prevention and treatment of obesity and obesity-related conditions for subjects in need thereof.
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