DIRECT REPROGRAMMING OF SOMATIC CELLS USING NON-INTEGRATING VECTORS

摘要

Provided herein are methods for producing induced pluripotent stem cells with the use of a non-integrating vector. Reprogramming of cells using a non-integrating vector (e.g., adenoviral vector) permits the generation of induced pluripotent stem cells that do not contain leftover viral genes that can be reactivated in the cell. This type of transient reprogramming is further contemplated for production of induced pluripotent stem cells for delivery to an individual.