发明名称 |
Synthetic heparin-binding factor analogs |
摘要 |
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
|
申请公布号 |
US7700563(B2) |
申请公布日期 |
2010.04.20 |
申请号 |
US20030644703 |
申请日期 |
2003.08.19 |
申请人 |
BIOSURFACE ENGINEERING TECHNOLOGIES, INC.;BROOKHAVEN SCIENCE ASSOCIATES |
发明人 |
PENA LOUIS A.;ZAMORA PAUL O.;LIN XINHUA;GLASS JOHN D. |
分类号 |
A61K38/00;A61K31/727;A61K38/24;A61L27/34;C07H21/04;C07K14/00;C07K14/50;C07K16/00;C08H1/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|