发明名称 |
Fc-interferon-beta fusion proteins |
摘要 |
Disclosed are Fc-interferon-beta (Fc-IFN-&bgr;) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-&bgr; fusion proteins include variants of the interferon-beta (IFN-&bgr;) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta. |
申请公布号 |
US7670595(B2) |
申请公布日期 |
2010.03.02 |
申请号 |
US20050167767 |
申请日期 |
2005.06.27 |
申请人 |
MERCK PATENT GMBH |
发明人 |
GILLIES STEPHEN D.;WATKINS NIGEL JOHN;BAKER MATTHEW PAUL;LO KIN-MING |
分类号 |
A61K38/21;A61K39/385;C07H21/04;C07K14/00;C12P21/04 |
主分类号 |
A61K38/21 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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