| 摘要 |
PROBLEM TO BE SOLVED: To provide a topical delayed-type hypersensitivity (DTH) inducer composition capable of efficiently delivering an effective amount of DTH to a host within a short time. SOLUTION: Topical patch preparation that includes a delayed-type hypersensitivity inducer, e.g., 1-dichloro-2,4-dinitrobenzene (DNCB), and a method for using the preparation are provided. The topical patch preparation is composed of an adhesive gel composition that is present on a support, where the adhesive gel composition includes the delayed-type hypersensitivity inducer, a water-soluble polymer gel, water and a water holding agent. In a method of using the topical patch preparation, the topical patch preparation is applied to a skin surface of a subject and maintained at the site of application for a period of time sufficient for an effective amount of the delayed-type hypersensitivity inducer to be administered to the subject, where the maintenance period does not exceed 60 minutes. COPYRIGHT: (C)2010,JPO&INPIT
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