| 摘要 |
A method for identifying a compound for modulating the formation of 14,15-LTC4 (Eoxin C4; EoxC4), 14,15-LTD4 (Eoxin D4; EoxD4), or 14,15-LTE4 (Eoxin E4; EoxE4) in a biological system. A method for identifying a compound with an anti-inflammatory effect, the method comprising testing the compound for an effect on formation and/or activity of 14,15-LTC4 (Eoxin C4; EoxC4), 14,15-LTD4 (Eoxin D4; EoxD4), or 14,15-LTE4 (Eoxin E4; EoxE4) in a biological system. A method of making an anti-inflammatory composition or Eoxin formation-modulating composition comprising (i) identifying an anti-inflammatory compound or Eoxin formation-modulating compound by a method of the invention; (ii) combining the compound with a pharmaceutically acceptable excipient or carrier.
|
