发明名称 INHIBITION OF ATP-MEDIATED, P2X7 DEPENDENT PATHWAYS BY PYRIDOXAL-5-PHOSPHATE AND VITAMIN B6 RELATED COMPOUNDS
摘要 P5P can be used as effective treatments for the modulation of P2X7, IL-1beta, and inflammation response, and for diseases in which prevention of P2X7-dependent pathways or prevention of release of IL-1beta is desirable, such as epithelial cancer, leukemia, brain tumors, spinal cord injury, tuberculosis, Alzheimer's Disease, neurodegenerative diseases, autosomal recessive polycystic kidney disease, diabetes, including type I diabetes, prostate cancer, and osteoporosis, bone formation and resorption.
申请公布号 US2009215727(A1) 申请公布日期 2009.08.27
申请号 US20060913654 申请日期 2006.05.05
申请人 MEDICURE INTERNATIONAL INC. 发明人 DOUGLAS DEBORAH
分类号 A61K31/675;A61P29/00 主分类号 A61K31/675
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