发明名称 |
CELL DEATH-INDUCING AGENT |
摘要 |
<p>To identify antigens of the 2D7 antibody, the present inventors cloned the 2D7 antigen. The results suggested that the 2D7 antigen is an HLA class I molecule. Based on this finding, the present inventors examined whether the 2D7 antibody has cell death-inducing activity. Nuclei fragmentation was observed when the 2D7 antibody was cross-linked with another antibody, indicating that cell-death was induced. Further, diabodies of the 2D7 antibody were found to have very strong cell death-inducing activities, even without the addition of another antibody. These results indicate that minibodies of an HLA-recognizing antibody can be used as cell death-inducing agents.</p> |
申请公布号 |
EP1561759(B9) |
申请公布日期 |
2009.08.26 |
申请号 |
EP20030751456 |
申请日期 |
2003.10.10 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA;OZAKI, SHUJI;ABE, MASAHIRO |
发明人 |
OZAKI, SHUJI;ABE, MASAHIRO;TSUCHIYA, MASAYUKI;KIMURA, NAOKI;KAWAI, SHIGETO |
分类号 |
C07K16/18;A61K39/395;A61P35/00;A61P37/02;A61P43/00;C07K14/74;C07K16/28;C12P21/08 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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