发明名称 |
Protease inhibitor conjugates and antibodies useful in immunoassay |
摘要 |
Activated haptens useful for generating immunogens to HIV protease inhibitors, immunogens useful for producing antibodies to HIV protease inhibitors, and antibodies and labeled conjugates useful in immunoassays for the HIV protease inhibitor saquinavir. The novel haptens feature an activated functionality at the central, non-terminal hydroxyl group. Also described are monoclonal antibodies specific for saquinavir having less than 10% cross-reactivity with lopinavir, nelfinavir, amprenavir, ritonavir, and indinavir, and a murine hybridoma producing said antibodies.
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申请公布号 |
US7569678(B2) |
申请公布日期 |
2009.08.04 |
申请号 |
US20070669397 |
申请日期 |
2007.01.31 |
申请人 |
ROCHE DIAGNOSTICS OPERATIONS, INC. |
发明人 |
SIGLER GERALD F.;HUI RAYMOND A.;DERAS INA;HUBER ERASMUS;VON DER ELTZ HERBERT W.;METZ SIGRUN;KERN PETER |
分类号 |
C07K17/06;C12N9/99;A61K39/00;A61P31/18;A61P43/00;C07D217/26;C07D239/10;C07D277/04;C07D277/28;C07D307/20;C07D401/12;C07D401/14;C07D403/12;C07D405/12;C07D417/14;C07D495/04;C07K1/10;C07K14/00;C07K14/765;C07K14/795;C07K16/00;C07K16/38;C07K16/44;C12N5/10;C12P21/08;G01N33/532 |
主分类号 |
C07K17/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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