发明名称 |
Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
摘要 |
Disclosed are novel polyclonal antibodies, which target respiratory syncyticilal virus (RSV), and novel high affinity antibody molecules reactive with RSV. The polyclonal antibodies may comprise antibody molecules which are reactive with both RSV protein F and RSV protein G, and preferably the polyclonal antibodies target a variety of epitopes on these proteins. The single antibody molecules of the invention are shown to exhibit affinities which provide for dissociation constants as low as in the picomolar range. Also disclosed are methods of producing the antibodies of the invention as well as methods of their use in treatment for RSV infection. |
申请公布号 |
ZA200806362(B) |
申请公布日期 |
2009.05.27 |
申请号 |
ZA20080006362 |
申请日期 |
2008.07.22 |
申请人 |
SYMPHOGEN A/S. |
发明人 |
LANTTO, JOHAN;STEINAA, LUCILLA;KOEFOED, KLAUS;NIELSEN, LARS S.;NIELSEN, HENRIETTE SCHJOENNING |
分类号 |
A61K;A61P;C07K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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