发明名称 |
NOVEL MODULATORS OF CELL CYCLE CHECKPOINTS AND THEIR USE IN COMBINATION WITH CHECKPOINT KINASE INHIBITORS |
摘要 |
In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.
|
申请公布号 |
CA2705092(A1) |
申请公布日期 |
2009.05.14 |
申请号 |
CA20082705092 |
申请日期 |
2008.11.05 |
申请人 |
SCHERING CORPORATION |
发明人 |
GUZI, TIMOTHY J.;PARRY, DAVID A.;LABROLI, MARC A.;DWYER, MICHAEL P.;PARUCH, KAMIL;ROSNER, KRISTEN E.;SHEN, RUICHAO;POPOVICI-MULLER, JANETA |
分类号 |
C07H19/073;A61K31/7068;A61P35/00;C07H19/067 |
主分类号 |
C07H19/073 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|