发明名称 |
Indoleacetic acid and indenacetic acid derivatives as therapeutic agents with reduced gastrointestinal toxicity |
摘要 |
The presently disclosed subject matter provides derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) that are characterized by substantially reduced cyclooxygenase inhibiting activity, yet retain the ability to interact with and modulate the activities of other polypeptides such as the class of peroxisome proliferators-activated receptors (PPARs) and gamma-secretase. Also provided are methods of using the derivatives to treat pathological disorders.
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申请公布号 |
US2009118290(A1) |
申请公布日期 |
2009.05.07 |
申请号 |
US20090319262 |
申请日期 |
2009.01.05 |
申请人 |
VANDERBILT UNIVERSITY |
发明人 |
MARNETT LAWRENCE J.;PRUSAKIEWICZ JEFFERY J.;FELTS ANDREW S.;JI CHUAN |
分类号 |
A61K31/5375;A61K31/165;A61K31/192;A61K31/405;A61K31/47;A61P35/00;C07C321/28;C07D215/14;C12N5/06 |
主分类号 |
A61K31/5375 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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