| 摘要 |
Lipoxin A4 and its analogs have been found to be effective in inhibiting apoptosis of retinal pigment epithelial cells induced by oxidative stress. Thus lipoxin A4 and its analogs, for example, lipoxin A4 epimer 15, can be used to prevent and treat retinal diseases due to the progressive degeneration of photoreceptors and retinal pigment epithelial cells (RPE cells), e.g., the dry form of age-related macula degeneration. They can also be combined with other compounds known to prevent apoptosis in retinal pigment epithelial cells, e.g., docosahexaenoic acid and neuroprotectin D1. |
