| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a new vector and viral vector, expressing a gene i.e., an exogenous nucleic acid sequence in objective target cells (e.g. T-cells, bone marrow cells, epithelial cells, hepatocytes, etc.). <P>SOLUTION: As the nucleic acid component of the vector, ≥1 natural promotor/enhancer region having a modified sequence segment, a gene or gene segment of ≥1 non-natural promotor/enhancer or a non-natural promotor, and a natural virus terminator, or a processing signal or its segment are included. The viral vector comprises the virus or a viral portion, having an adsorption component on its surface or envelope, wherein, one is for a packaging cell line and the other is for delivery to a target cell. The new method for propagating the vector or viral vector is also provided. <P>COPYRIGHT: (C)2009,JPO&INPIT |
