Novel compounds having selective inhibiting effect at GSK3

摘要

Disclosed are compounds of formula (I) wherein: Z is N; P is phenyl; Y is CONR5, NR5CO, SO2NR5, NR5SO2, CH2NR5, NR5CONR5, CH2CO, CO or CH2O; X is N; P is phenyl; Q is alkyl, alkenyl or alkynyl; R is C0-6alkyl(SO2)NR1R2; and the remainder of the substituents are as described in the specification. Compounds of the type disclosed have a selective inhibiting effect on glycogen synthase kinase 3 (GSK3) and are useful for the treatment or prevention of diseases such as Alzheimer's disease, Parkinson's disease, frontotemporal dementia Parkinson's type, Parkinson dementia complex of Guam, HIV dementia, diseases with associated neurofibrillar tangle pathologies and dementia pugilistica.