发明名称 Activated Protein C Inhibits Undesirable Effects of Plasminogen Activator in the Brain
摘要 Activated protein C (APC), a prodrug, and/or a variant of APC may be used to inhibit undesirable effects of plasminogen activator: e.g., apoptosis or cell death of neurons and endothelial cells, brain hemorrhage or intracerebral bleeding, and/or tissue damage in a subject's brain. Inhibition appears to act through the extrinsic pathway of death receptor signal transduction. This represents an improvement in treatment using plasminogen activator (e.g., fibrinolysis). By reducing undesirable effects, the window for fibrinolytic therapy by plasminogen activator may be widened.
申请公布号 US2008305100(A1) 申请公布日期 2008.12.11
申请号 US20050632850 申请日期 2005.07.25
申请人 ZLOKOVIC BERISLAV V;LIU DONG;CHENG TONG;GUO HUANG 发明人 ZLOKOVIC BERISLAV V.;LIU DONG;CHENG TONG;GUO HUANG
分类号 A61K38/48;A61P9/00;C40B30/06 主分类号 A61K38/48
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