发明名称 |
Method of Screening Baff Suppressor or Inhibitor |
摘要 |
A method of screening a novel BAFF suppressor or inhibitor. More specifically speaking, a method which comprises adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell to thereby induce the production of BAFF by the cell; a method of screening a substance capable of suppressing the expression or activity of BAFF which comprises adding a test substance to a BAFF-production system prepared by adding a combination of TPA with ionomycin and/or an anti-CD3 antibody to a cultured human cell and measuring the expression amount and/or the activity of BAFF in the BAFF-production system; and a BAFF production inducer for a BAFF-producing cell which contains a combination of TPA with ionomycin and/or an anti-CD3 antibody.
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申请公布号 |
US2008305502(A1) |
申请公布日期 |
2008.12.11 |
申请号 |
US20050662795 |
申请日期 |
2005.09.14 |
申请人 |
KOWA COMPANY, LTD. |
发明人 |
TAKEUCHI TSUTOMU;TSUZAKA KENSEI;YOSHIMOTO KEIKO |
分类号 |
G01N33/574;C07K16/18;C12N9/50;C12P21/04;G01N33/573 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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