发明名称 |
OXIME COMPOUNDS AND THE USE THEREOF |
摘要 |
The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is O, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain. |
申请公布号 |
WO2008008398(A3) |
申请公布日期 |
2008.12.11 |
申请号 |
WO2007US15827 |
申请日期 |
2007.07.12 |
申请人 |
SHIONOGI & CO., LTD.;EURO-CELTIQUE S.A;MATSUMURA, AKIRA;MIKAMIYAMA, HIDENORI;TSUNO, NAOKI;KYLE, DONALD, J.;SHAO, BIN;YAO, JIANGCHAO |
发明人 |
MATSUMURA, AKIRA;MIKAMIYAMA, HIDENORI;TSUNO, NAOKI;KYLE, DONALD, J.;SHAO, BIN;YAO, JIANGCHAO |
分类号 |
A61K31/40;C07D207/14 |
主分类号 |
A61K31/40 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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